Key result
Genetically-predicted waist circumference was inversely related to blood adiponectin concentration (β = -0.27; 95% CI -0.36, -0.19; P=2*10-11), whereas hip circumference was positively associated.
Why the study?
Does abdominal versus gluteofemoral fat accumulation differentially affect blood adiponectin concentration in adults?
Observational (n=242,090)
Yes
Does abdominal versus gluteofemoral fat accumulation differentially affect blood adiponectin concentration in adults?
Effect estimate: β -0.27 (95% CI -0.36, -0.19)
p-value: p=2*10-11
Abdominal fat accumulation reduces circulating adiponectin, whereas gluteofemoral fat accumulation appears to exert a protective effect by increasing adiponectin levels.
No takes yet. Share an insight, caveat, or question.
No immediate clinical implications; extends GWAS evidence for depot-specific adiposity effects on adiponectin.
Borges et al. (2017) conducted an observational in Obesity-induced hypoadiponectinaemia (n=242,090). Abdominal and gluteofemoral fat accumulation was evaluated on Blood adiponectin concentration (β -0.27, 95% CI -0.36, -0.19, p=2*10-11). Genetically-predicted waist circumference was inversely related to blood adiponectin concentration (β = -0.27; 95% CI -0.36, -0.19; P=2*10-11), whereas hip circumference was positively associated.
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