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December 9, 2024Infection Genetics and EvolutionOpen Access

Prevalence and drug resistance analysis of hepatitis C virus genotypes in Heilongjiang, China

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Authors

BDBo DuLYLe YuKZKun Zhou

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Overview

Randomized trial analyzes hepatitis C virus genotypes and drug resistance in Heilongjiang, suggesting a need for enhanced monitoring.

Key Points

  • This research aims to analyze the prevalence and drug resistance of hepatitis C virus genotypes in Heilongjiang, China.
  • 7019 specimens were tested for hepatitis C virus genotype identification.
  • Autoregressive Integrated Moving Average model used to predict infection trends from 2024 to 2030.
  • Sanger sequencing performed on specific genotypes to investigate resistance-associated substitutions.
  • HCV genotypes 1b and 2a predominated in Heilongjiang, comprising 47.51% and 43.85%, respectively.
  • The proportion of resistance-associated substitutions was 73.47% in GT1b and 15.22% in GT2a, with 100% in GT1b's NS5B region.
  • New resistance-related mutations K107R and P206S were identified, correlating with drug efficacy.

Cite This Study

Du et al. (2024) studied this question.

synapsesocial.com/papers/6a4228a547fac82bfd15c2a5https://doi.org/10.1016/j.meegid.2024.105700
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