Key result
Coronary artery spasm is primarily caused by smooth muscle hypercontraction involving protein kinase C and Rho-kinase, suggesting Rho-kinase as a novel therapeutic target.
Rho-kinase is a key mediator of coronary artery smooth muscle hypercontraction and represents a potential therapeutic target for coronary artery spasm.
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Local hyperreactivity may drive coronary spasm across ischemic syndromes; leaves open mechanism-specific trials before practice change.
Hiroaki Shimokawa (2000) conducted a review in Coronary artery spasm. Rho-kinase inhibition was evaluated. Coronary artery spasm is primarily caused by smooth muscle hypercontraction involving protein kinase C and Rho-kinase, suggesting Rho-kinase as a novel therapeutic target.
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