March 21, 2000Circulation
Inhibition of Myosin Phosphatase by Upregulated Rho-Kinase Plays a Key Role for Coronary Artery Spasm in a Porcine Model With Interleukin-1β
Why the study?
Does Rho-kinase inhibition with Y-27632 prevent serotonin-induced coronary hypercontractions in a porcine model of IL-1beta-induced coronary spasm?
Population
Porcine model with left coronary artery chronically treated from the adventitia with IL-1beta-bound…
Comparison
Y-27632 administered during serotonin-induced… vs Control segment of the coronary artery
Design
Preclinical
Follow-up
2 weeks after operation
Authors
Discussion
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Member takes
Implication
Attenuates hypercontractions in porcine model; leaves open whether Rho-kinase inhibition offers a clinical target for vasospastic angina.
Structured PICO
Does Rho-kinase inhibition with Y-27632 prevent serotonin-induced coronary hypercontractions in a porcine model of IL-1beta-induced coronary spasm?
P
Population
Porcine model with left coronary artery chronically treated from the adventitia with IL-1beta-bound microbeads to induce coronary artery spasm
I
Intervention
Y-27632 (a specific inhibitor of Rho-kinase) administered during serotonin-induced contractions
C
Comparator
Control segment of the coronary artery
O
Outcome
Coronary hypercontractions and phosphorylation of the myosin-binding subunit of myosin phosphatase (MBS)surrogate
Upregulation of Rho-kinase plays a key role in coronary artery spasm by inhibiting myosin phosphatase, suggesting a potential therapeutic target for vasospastic angina.
Cite This Study
Kandabashi et al. (2000) studied this question.