September 24, 2018European Journal of Preventive Cardiology
Frailty as an instrument for evaluation of elderly patients with non-ST-segment elevation myocardial infarction: A follow-up after more than 5 years
Key result
Frailty was independently associated with higher long-term all-cause mortality compared to non-frail patients (85.9% vs 53.8%; HR 2.06; 95% CI 1.51-2.81; P<0.001).
Why the study?
Does frailty predict long-term all-cause mortality in elderly patients hospitalized for NSTEMI?
Population
307 patients aged 75 years or older hospitalised for non-ST-segment elevation myocardial infarction
Comparison
Frail status vs Non-frail status
Design
Cohort
Follow-up
median 6.7 years
Authors
Discussion
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Member takes
Implication
May aid risk stratification; leaves open whether frailty interventions improve survival in cardiac cohorts.
Study Design
Type
Observational (n=307)
Multicenter
Yes
Structured PICO
Does frailty predict long-term all-cause mortality in elderly patients hospitalized for NSTEMI?
P
Population
307 patients aged 75 years or older hospitalized for non-ST-segment elevation myocardial infarction, followed for a median of 6.7 years.
E
Exposure
Frail status (degree 5-7 on the Canadian Study of Health and Aging clinical frailty scale)
C
Comparator
Non-frail status
O
Outcome
All-cause mortality at long-term follow-up (median 6.7 years)hard clinical
Main Result
Hazard Ratio: 2.06 (95% CI 1.51–2.81)
Absolute Event Rate: 85.9% vs 53.8%
p-value: p=< 0.001
Frailty is a strong, independent predictor of long-term all-cause mortality in elderly patients hospitalized for NSTEMI, highlighting its utility alongside comorbidity indices for risk stratification.
Cite This Study
Ekerstad et al. (2018) conducted an observational in non-ST-segment elevation myocardial infarction (n=307). Frailty vs. Non-frail was evaluated on all-cause mortality (HR 2.06, 95% CI 1.51-2.81, p=< 0.001). Frailty was independently associated with higher long-term all-cause mortality compared to non-frail patients (85.9% vs 53.8%; HR 2.06; 95% CI 1.51-2.81; P<0.001).