Key result
Patients with hypertrophic cardiomyopathy exhibited a significantly greater maximal change in coronary sinus pH during dipyridamole stress compared to controls (0.082 vs 0.005, P=0.02).
Why the study?
Does dipyridamole stress induce greater coronary sinus pH changes (indicating myocardial ischemia) in patients with hypertrophic cardiomyopathy compared to controls?
Case-Control (n=17)
Does dipyridamole stress induce greater coronary sinus pH changes (indicating myocardial ischemia) in patients with hypertrophic cardiomyopathy compared to controls?
Absolute Event Rate: 0.082% vs 0.005%
p-value: p=0.02
Coronary sinus pH monitoring during dipyridamole stress demonstrates a significantly greater pH decline in HCM patients compared to controls, providing evidence that chest pain in HCM is caused by myocardial ischemia.
No takes yet. Share an insight, caveat, or question.
Coronary sinus pH monitoring may detect ischemia in HCM; leaves open its diagnostic role pending prospective validation.
Elliott et al. (1996) conducted a case-control in Hypertrophic cardiomyopathy (n=17). Hypertrophic cardiomyopathy vs. Controls with atypical pain and normal coronary angiograms was evaluated on Maximal change in coronary sinus pH during dipyridamole stress (p=0.02). Patients with hypertrophic cardiomyopathy exhibited a significantly greater maximal change in coronary sinus pH during dipyridamole stress compared to controls (0.082 vs 0.005, P=0.02).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: