Key result
CK-MB peaking at 90 minutes after thrombolytic therapy significantly correlated with successful reperfusion, occurring in 95.45% of patients with peaking CK-MB compared to 16.66% without (p=0.001).
Why the study?
The study was conducted to evaluate the value of non-invasive markers, specifically ST resolution and CK-MB peaking, in detecting reperfusion after thrombolysis in acute myocardial infarction.
Do non-invasive markers (ST resolution and CK-MB peaking) accurately detect reperfusion after thrombolytic therapy in patients with acute myocardial infarction?
Cross-Sectional (n=100)
No
Do non-invasive markers (ST resolution and CK-MB peaking) accurately detect reperfusion after thrombolytic therapy in patients with acute myocardial infarction?
Absolute Event Rate: 95.45% vs 16.66%
p-value: p=0.001
CK-MB peaking and ST-segment resolution at 90 minutes serve as reliable non-invasive markers for detecting successful coronary reperfusion after thrombolytic therapy in acute myocardial infarction.
Validates thrombolytic efficacy for most AMI patients; extends RCT support for CK-MB as non-invasive reperfusion marker.
Acute myocardial infarction is a potentially life-threatening condition and patient may die or become disabled in the prime of life. This hospital based observational study was conducted in medicine and cardiology department of Faridpur Medical College Hospital from 25th March 2015 to 24th September 2015 among patients with acute myocardial infarction to see the value of non-invasive markers (ST resolution and CK-MB peaking) in the detection of reperfusion after thrombolysis. Total 100 consecutive patients with their first myocardial infarction undergoing thrombolytic therapy were included in the study. Study shows maximum number of patients 49 (49%) were between 51-60 years’ age group, next 26 (26%) were between the age group of 61-70 years. Total 78% were male and 22% were female & majority of the acute myocardial infarction were inferior (57%). Present study showed that 86% of patients succeed to reperfusion and 14% fail to reperfusion. Blood samples were taken on admission and 90 minutes after thrombolytic therapy. The times at which the concentrations of the CK-MB markers peaked significantly at 90 minutes in patients of reperfused group (88%) than in those of not reperfused (12%). These results emphasize the release of these markers when reperfusion is established. Faridpur Med. Coll. J. 2025;20(1): 36-40
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Karmaker et al. (2025) conducted a cross-sectional in Acute Myocardial Infarction (n=100). CK-MB peaking at 90 minutes vs. No CK-MB peaking at 90 minutes was evaluated on Successful reperfusion (defined as ≥50% resolution of ST segment elevation) (p=0.001). CK-MB peaking at 90 minutes after thrombolytic therapy significantly correlated with successful reperfusion, occurring in 95.45% of patients with peaking CK-MB compared to 16.66% without (p=0.001).
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