June 1, 1988European Heart Journal
Non-invasive assessment of infarct reperfusion: the predictive power of the time to peak value of myoglobin, CKMB, and CK in serum
Why the study?
Does the time to peak value of serum myoglobin, CKMB, and CK accurately predict infarct reperfusion in patients with acute myocardial infarction?
Population
44 patients with acute myocardial infarction
Comparison
Time to peak value analysis of serum myoglobin… vs Angiographically confirmed recanalization status
Design
Cohort
Authors
Discussion
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Member takes
Implication
May support noninvasive reperfusion assessment with myoglobin only after early recanalization; leaves open prospective validation before practice change.
Structured PICO
Does the time to peak value of serum myoglobin, CKMB, and CK accurately predict infarct reperfusion in patients with acute myocardial infarction?
P
Population
44 patients with acute myocardial infarction (8 with recanalization within 3.5 hours, 18 with recanalization after 3.5 hours, 10 with persistent occlusion, and 8 where thrombolysis was not attempted)
I
Intervention
Time to peak value analysis of serum myoglobin, CKMB, and CK
C
Comparator
Angiographically confirmed recanalization status (intracoronary streptokinase vs no thrombolysis)
O
Outcome
Probability of correct classification of infarct reperfusionsurrogate
Time to peak value of serum myoglobin, CKMB, and CK can reliably predict infarct reperfusion non-invasively only if recanalization is achieved early (<3.5 hours) after symptom onset.
Cite This Study
Katus et al. (1988) studied this question.