September 16, 1997Circulation
Assessment of Coronary Reperfusion After Thrombolysis With a Model Combining Myoglobin, Creatine Kinase–MB, and Clinical Variables
Why the study?
Does adding a 90-minute myoglobin measurement to clinical variables and CK-MB levels improve the noninvasive prediction of coronary reperfusion after thrombolysis in patients with myocardial infarction?
Population
96 patients with myocardial infarction enrolled in a study of front-loaded thrombolysis who underwent…
Comparison
A predictive model combining a single myoglobin… vs Established predictive model containing clinical…
Design
Cohort
Follow-up
90 minutes
Authors
Discussion
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Member takes
Implication
May support myoglobin-augmented models for reperfusion prediction post-thrombolysis; leaves open prospective validation and outcome impact.
Structured PICO
Does adding a 90-minute myoglobin measurement to clinical variables and CK-MB levels improve the noninvasive prediction of coronary reperfusion after thrombolysis in patients with myocardial infarction?
P
Population
96 patients with myocardial infarction enrolled in a study of front-loaded thrombolysis who underwent 90-minute angiography
I
Intervention
A predictive model combining a single myoglobin measurement obtained 90 minutes after the start of thrombolysis, clinical variables (time from symptom onset to thrombolysis and chest pain grade), and creatine kinase-MB levels
C
Comparator
Established predictive model containing clinical variables and creatine kinase-MB measures alone
O
Outcome
Prediction of coronary reperfusion (assessed by TIMI flow grade at 90-minute angiography)surrogate
A single myoglobin measurement at 90 minutes post-thrombolysis, combined with clinical variables and CK-MB, provides excellent noninvasive prediction of coronary reperfusion.
Cite This Study
Christenson et al. (1997) studied this question.