Biochemical markers of thrombolytic success
Why the study?
Does monitoring biochemical markers accurately detect successful reperfusion following thrombolytic therapy and assist in risk stratification after percutaneous intervention in acute myocardial infarction patients?
Population
Acute myocardial infarction patients receiving thrombolytic therapy or percutaneous intervention
Design
Review
Authors
Discussion
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Member takes
Implication
May aid post-thrombolysis reperfusion detection; leaves open prospective validation and TIMI 2/3 differentiation before practice change.
Structured PICO
Does monitoring biochemical markers accurately detect successful reperfusion following thrombolytic therapy and assist in risk stratification after percutaneous intervention in acute myocardial infarction patients?
P
Population
Acute myocardial infarction patients receiving thrombolytic therapy or percutaneous intervention
I
Intervention
Monitoring biochemical markers (myoglobin, cardiac troponin I, cardiac troponin T, and CK MB mass)
O
Outcome
Detection of successful reperfusion within 90 minutes following initiation of therapy and short-term (30-day) risk stratificationsurrogate
While biochemical markers show high sensitivity and specificity for detecting early reperfusion after thrombolysis, their clinical utility is limited by the inability to differentiate TIMI 3 from TIMI 2 flow and a lack of prospective validation.
Limitations
- Small number of patients studied
- No prospective studies reported
- Cannot differentiate TIMI 3 flow from TIMI 2 flow
Cite This Study
Fred S. Apple (1999) studied this question.