February 1, 1992American Journal of Clinical Pathology
Acute Myocardial Infarction and Coronary Reperfusion: Serum Cardiac Markers for the 1990s
Key result
Serial CK-MB measurement remains the gold standard for early detection of acute myocardial infarction, while the clinical utility of troponin and myoglobin remains to be established.
Why the study?
What is the clinical utility of serum cardiac markers like CK-MB for the early detection of AMI and reperfusion in the emergency department?
Population
Patients with suspected acute myocardial infarction (AMI) in the emergency department
Design
Review
Authors
Discussion
Loading...
Member takes
Implication
Rapid CK-MB aids ED triage and avoids missed AMI with nondiagnostic ECGs; reinforces serial enzyme protocols as laboratory standard.
Structured PICO
What is the clinical utility of serum cardiac markers like CK-MB for the early detection of AMI and reperfusion in the emergency department?
P
Population
Patients with suspected acute myocardial infarction (AMI) in the emergency department
E
Exposure
Measurement of serial CK-MB in serum and other cardiac markers (troponin isoenzymes, CK isoforms, myoglobin)
O
Outcome
Early detection of AMI and reperfusion
Serial CK-MB testing is recommended as the gold standard for early AMI detection, facilitating rapid triage and thrombolytic therapy decisions in the emergency department.
Cite This Study
Fred S. Apple (1992) conducted a review in Acute Myocardial Infarction. Serum Cardiac Markers (CK-MB) was evaluated. Serial CK-MB measurement remains the gold standard for early detection of acute myocardial infarction, while the clinical utility of troponin and myoglobin remains to be established.