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August 1, 1993Clinical Chemistry

Early diagnosis of acute myocardial infarction with use of a rapid immunochemical assay of creatine kinase MB isoenzyme

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Key result

A rapid immunochemical assay of CK-MB demonstrated an immediate sensitivity of 52% and a specificity of 97% for diagnosing acute myocardial infarction upon hospital admission.

Why the study?

Does a rapid immunochemical assay of CK-MB improve the early diagnosis of acute myocardial infarction in patients presenting with chest pain?

Population

195 patients presenting with chest pain and referred acutely for cardiological assessment.

Comparison

Rapid immunochemical assay of creatine kinase MB… vs Independent diagnosis based on…

Design

Cohort

Authors

DCDavid R. CollinsUNSW SydneyDWD. J. WrightLinköping UniversityMRM. G. RinslerNorthwick Park Hospital

Discussion

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Implication

Low sensitivity limits ruling out AMI on admission; leaves open utility in equivocal ECGs pending prospective validation.

Study Design

Type

Cross-Sectional (n=195)

Structured PICO

Does a rapid immunochemical assay of CK-MB improve the early diagnosis of acute myocardial infarction in patients presenting with chest pain?

P
Population
195 patients presenting with chest pain and referred acutely for cardiological assessment.
E
Exposure
Rapid immunochemical assay of creatine kinase MB (CK-MB) isoenzyme from blood taken immediately on admission, with results obtained within 30 minutes.
C
Comparator
Independent diagnosis based on electrocardiograms and conventional cardiac enzyme profiles.
O
Outcome
Diagnostic sensitivity and specificity for acute myocardial infarction.surrogate

A rapid CK-MB assay provides high specificity (97%) but low sensitivity (52%) for early AMI diagnosis on admission, though it can usefully guide thrombolytic therapy in patients with equivocal ECGs.

Cite This Study

Collins et al. (1993) conducted a cross-sectional in Acute myocardial infarction (n=195). Rapid immunochemical assay of creatine kinase MB isoenzyme vs. Electrocardiograms and conventional cardiac enzyme profiles was evaluated on Diagnosis of acute myocardial infarction. A rapid immunochemical assay of CK-MB demonstrated an immediate sensitivity of 52% and a specificity of 97% for diagnosing acute myocardial infarction upon hospital admission.

synapsesocial.com/papers/6a9c0bdedd01f5faf99087dfhttps://doi.org/10.1093/clinchem/39.8.1725
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Early Diagnosis of Acute Myocardial Infarction by CK-MB Mass Measurements1992 · 70 citations
  2. 2Use of rapid serial sampling of creatine kinase MB for very early detection of myocardial infarction in patients with acute chest pain1992 · 75 citations
  3. 3Use of a Rapid Assay of Subforms of Creatine Kinase MB to Diagnose or Rule Out Acute Myocardial Infarction1994 · 327 citations
  4. 4Evaluation of Creatine Kinase and Creatine Kinase—MB for Diagnosing Myocardial Infarction1987 · 91 citations
  5. 5Early diagnosis of acute myocardial infarction by rapid analysis of creatine kinase isoenzyme-3 (CK-MM) sub-types.1987 · 54 citations