Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 1992Annals of Clinical Biochemistry International Journal of Laboratory MedicineOpen Access

Early Diagnosis of Acute Myocardial Infarction by CK-MB Mass Measurements

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Do serial measurements of CK and CK-MB activity and concentration improve the early diagnosis of acute myocardial infarction in patients with cardiac symptoms?

Population

73 patients admitted to the coronary care unit with cardiac symptoms of 12 h duration or less

Design

Cohort

Follow-up

8 hours

Authors

PCPaul CollinsonGeneral / Preventive / LipidsSRS B RosalkiLaboratoire de BiochimieTKTomomi KuwanaUniversity of Iowa

Discussion

Loading...

Member takes

Implication

May support 4-hour AMI diagnosis with combined CK metrics; leaves open prospective validation versus modern troponin protocols.

Structured PICO

Do serial measurements of CK and CK-MB activity and concentration improve the early diagnosis of acute myocardial infarction in patients with cardiac symptoms?

P
Population
73 patients admitted to the coronary care unit with cardiac symptoms of 12 h duration or less
I
Intervention
Serial measurement of creatine kinase (CK) and CK-MB activity and concentration over an 8 h period following admission
O
Outcome
Accurate diagnosis of acute myocardial infarctionsurrogate

Serial measurement of CK slope combined with CK-MB concentration enables accurate diagnosis of acute myocardial infarction within 4 hours of admission.

Cite This Study

Collinson et al. (1992) studied this question.

synapsesocial.com/papers/6a83ad1cd65172829ee656a8https://doi.org/10.1177/000456329202900105
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Diagnosis of acute myocardial infarction from sequential enzyme measurements obtained within 12 hours of admission to hospital.1989 · 36 citations
  2. 2Early Diagnosis of Myocardial Infarction by Timed Sequential Enzyme Measurements1988 · 60 citations
  3. 3Evaluation of Creatine Kinase and Creatine Kinase—MB for Diagnosing Myocardial Infarction1987 · 91 citations
  4. 4Role of rapid immunoassays for urgent ("stat") determinations of creatine kinase isoenyme MB.1989 · 43 citations
  5. 5Application of the Regression Coefficient to Timed Serial Serum Creatine Kinase Measurements in the Early Diagnosis of Myocardial Infarction1989 · 12 citations