Key result
Sequential CK slope measurements within 12 hours yielded 100% sensitivity and 94% specificity for diagnosing myocardial infarction, compared to 94% and 90% using upper reference limits alone.
Why the study?
Does sequential measurement of CK and CK-MB slopes within 12 hours of admission accurately diagnose acute myocardial infarction in patients with recent chest pain?
Population
65 patients with recent chest pain admitted to the coronary care unit
Comparison
Sequential measurement of serum creatine kinase… vs Retrospective diagnosis using all available…
Design
Cohort
Follow-up
12 hours
Authors
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May support earlier MI diagnosis in chest pain cohorts; hypothesis-generating and requires prospective validation before changing practice.
Observational (n=65)
Does sequential measurement of CK and CK-MB slopes within 12 hours of admission accurately diagnose acute myocardial infarction in patients with recent chest pain?
Sequential measurement of CK and CK-MB slopes within 12 hours of admission provides highly sensitive and specific early diagnosis of acute myocardial infarction, potentially allowing for earlier discharge or transfer.
Collinson et al. (1989) conducted an observational in acute myocardial infarction (n=65). Sequential CK and CK-MB slope measurements vs. Upper reference limits alone was evaluated on Diagnosis of myocardial infarction. Sequential CK slope measurements within 12 hours yielded 100% sensitivity and 94% specificity for diagnosing myocardial infarction, compared to 94% and 90% using upper reference limits alone.
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