Why the study?
Do serial measurements of serum creatine kinase improve the diagnosis and exclusion of acute myocardial infarction in patients presenting with acute chest pain?
Population
n=94 patients presenting to St Thomas' Hospital, London, with acute chest pain of less than 12 h duration.
Comparison
Rapid sequential measurements of serum creatine… vs Clinical history and electrocardiographic…
Design
Cohort
Follow-up
12 hours
Authors
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Serial CK may aid MI exclusion mainly in patients with prior heart disease; leaves open broader utility and needs prospective validation.
Do serial measurements of serum creatine kinase improve the diagnosis and exclusion of acute myocardial infarction in patients presenting with acute chest pain?
Serial serum CK measurements are primarily useful for excluding acute myocardial infarction in patients presenting with chest pain who have a prior history of heart disease.
Johnston et al. (1996) studied this question.
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