January 1, 1987Archives of Internal Medicine
Evaluation of Creatine Kinase and Creatine Kinase—MB for Diagnosing Myocardial Infarction
Why the study?
Does a single sampling of total CK or CK-MB accurately diagnose acute myocardial infarction in emergency room patients with acute chest pain?
Population
639 patients presenting to the emergency room with acute chest pain (386 admitted, 253 discharged)
Design
Cohort
Authors
Discussion
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Member takes
Implication
Single CK/CK-MB sampling lacks sensitivity to exclude AMI in ER chest pain; leaves open optimal serial or biomarker strategies for future validation.
Structured PICO
Does a single sampling of total CK or CK-MB accurately diagnose acute myocardial infarction in emergency room patients with acute chest pain?
P
Population
639 patients presenting to the emergency room with acute chest pain (386 admitted, 253 discharged)
I
Intervention
Single sampling of total creatine kinase (CK) alone or total CK with CK-MB (if total CK elevated)
O
Outcome
Diagnosis of acute myocardial infarction (sensitivity and specificity)surrogate
A single sampling of CK and CK-MB in the emergency room has too low sensitivity to safely exclude myocardial infarction or justify discharging a patient.
Cite This Study
Thomas H. Lee (1987) studied this question.