Key result
A paired creatine kinase test showing a >20% increment in the first four hours yielded 84.4% sensitivity and 85.8% specificity for diagnosing acute myocardial infarction.
Why the study?
Does a paired creatine kinase test accurately diagnose acute myocardial infarction in patients with suspected AMI and a non-diagnostic ECG?
Population
n=345 consecutive admissions with suspected acute myocardial infarction and an inconclusive initial…
Design
Cohort
Authors
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May support early AMI diagnosis with nondiagnostic ECG; leaves open prospective validation before changing troponin-based practice.
Observational (n=345)
Does a paired creatine kinase test accurately diagnose acute myocardial infarction in patients with suspected AMI and a non-diagnostic ECG?
Effect estimate: Sensitivity 84.4% (95% CI 75.5-93.3)
A paired creatine kinase test with measurements separated by four hours provides high sensitivity and specificity for diagnosing acute myocardial infarction in patients with non-diagnostic ECGs.
Hingorani et al. (1997) conducted an observational in Suspected acute myocardial infarction (n=345). Paired creatine kinase (CK) test was evaluated on Diagnosis of acute myocardial infarction (Sensitivity 84.4%, 95% CI 75.5-93.3). A paired creatine kinase test showing a >20% increment in the first four hours yielded 84.4% sensitivity and 85.8% specificity for diagnosing acute myocardial infarction.
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