Key result
Local application of Angiotensin II significantly improved functional recovery after sciatic nerve crush in adult rats, increasing toe spread distance (10.2 vs 8.73 mm, P<0.01).
Why the study?
Does local application of Angiotensin II improve functional recovery in adult rats after sciatic nerve crush?
Population
Adult rats with sciatic nerve crush
Comparison
Angiotensin II (10, 10, 10 M) applied locally… vs Control group
Design
Preclinical
Follow-up
20 days
Authors
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Hypothesis-generating for AT2 agonism in rodent nerve repair; leaves open translation to human peripheral nerve injury.
Does local application of Angiotensin II improve functional recovery in adult rats after sciatic nerve crush?
Absolute Event Rate: 10.2% vs 8.73%
p-value: p=<0.01
Angiotensin II accelerates functional recovery after peripheral nerve injury in rats via the AT2 receptor and NF-kappaB activation.
Reinecke et al. (2003) studied sciatic nerve crush. Angiotensin II (ANG II) vs. control group was evaluated on toe spread distance after 20 days (p=<0.01). Local application of Angiotensin II significantly improved functional recovery after sciatic nerve crush in adult rats, increasing toe spread distance (10.2 vs 8.73 mm, P<0.01).
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