Key result
The proposed three-filament model accurately predicts history-dependent force generation in half sarcomeres for eccentric and concentric contractions, and predicts activation-dependent forces for stretches beyond actin-myosin overlap.
A novel three-filament model incorporating titin-actin interaction improves upon classical cross-bridge models by accurately predicting history-dependent force generation in skeletal muscle.
Extends cross-bridge models for eccentric force prediction; hypothesis-generating for titin-actin roles but requires validation before any clinical use.
We propose and examine a three filament model of skeletal muscle force generation, thereby extending classical cross-bridge models by involving titin-actin interaction upon active force production. In regions with optimal actin-myosin overlap, the model does not alter energy and force predictions of cross-bridge models for isometric contractions. However, in contrast to cross-bridge models, the three filament model accurately predicts history-dependent force generation in half sarcomeres for eccentric and concentric contractions, and predicts the activation-dependent forces for stretches beyond actin-myosin filament overlap.
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Schappacher‐Tilp et al. (2015) studied Skeletal muscle force generation. Three-filament model involving titin-actin interaction vs. Classical cross-bridge model was evaluated on Force generation in half sarcomeres for eccentric and concentric contractions. The proposed three-filament model accurately predicts history-dependent force generation in half sarcomeres for eccentric and concentric contractions, and predicts activation-dependent forces for stretches beyond actin-myosin overlap.
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