Key result
Experimental infection of sheep and goats with serotype O foot-and-mouth disease virus via the coronary band route resulted in clinical signs at 2-5 days, whereas intra-dermo-lingual challenge caused viremia without clinical signs.
Why the study?
Foot-and-mouth disease is an economically important contagious disease of livestock, but data on its pathogenesis in goats are limited.
The study demonstrates the pathogenesis of serotype O foot-and-mouth disease virus in Indian sheep and goats, showing that clinical signs depend on the route of inoculation.
Experimental FMD challenge via coronary routes elicits signs in goats at 2-5 days; leaves open optimal models for natural pathogenesis and control studies.
Foot-and-mouth disease (FMD) is an economically important contagious disease of livestock mainly cattle, buffalo, sheep, goats, and pig. There is limited data available on pathogenesis of foot and mouth disease in goats. In the study, the sheep and goats were infected experimentally with a serotype O foot-and-mouth disease virus by different challenge routes. The sheep and goats challenged by coronary band route and coronary band and intra-dermo-lingual route exhibited FMD clinical signs at 2-5 days post challenge. Whereas intra-dermo-lingual challenged sheep and goats did not exhibit FMD clinical signs. Live virus could be isolated from blood of infected sheep and goats at 2-5 days post challenge. Viral RNA could be detected from blood of infected sheep and goats at 1-10 days post challenge. The neutralizing antibody titre was detected at 10 days post challenge and maintained up to 35 days post challenge in all infected sheep and goats. Non structural protein (NSP) antibodies were detected as early as 5-10 days post challenge and remain positive up to 35 days post challenge in the infected sheep and goats. In conclusion, the pathogenesis of sheep and goats with serotype O foot and mouth disease virus by different challenge routes could be demonstrated.
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Madhanmohan et al. (2020) studied Foot and Mouth Disease (n=16). Experimental infection with serotype O foot-and-mouth disease virus vs. Unchallenged control was evaluated on Development of clinical FMD signs and viremia. Experimental infection of sheep and goats with serotype O foot-and-mouth disease virus via the coronary band route resulted in clinical signs at 2-5 days, whereas intra-dermo-lingual challenge caused viremia without clinical signs.
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