Key result
Proficiency testing of creatine kinase and CK-MB across Ontario laboratories revealed a wide dispersion of results and reference ranges between and among identical analyzer systems.
Observational (n=230)
Yes
Significant variability in CK and CK-MB measurements across laboratories highlights the need for standardized reference materials to ensure reliable clinical and epidemiological data.
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High inter-laboratory CK/CK-MB variability warrants cautious clinical interpretation; leaves open needs for improved assay standardization.
Henderson et al. (1998) conducted an observational in Proficiency testing of cardiac enzymes (n=230). Proficiency testing of creatine kinase and CK-MB was evaluated on Analytical performance and dispersion of results between different analyzer systems. Proficiency testing of creatine kinase and CK-MB across Ontario laboratories revealed a wide dispersion of results and reference ranges between and among identical analyzer systems.
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