Key result
TAVR was associated with higher early mortality (≤90 days) compared to matched controls (HR 3.90; 95% CI 2.82-5.39; p<0.001), but late mortality (>90 days) was similar between groups.
Why the study?
Does survival in aortic stenosis patients treated with TAVR differ from an age- and sex-matched background population?
Cohort (n=16,042)
Does survival in aortic stenosis patients treated with TAVR differ from an age- and sex-matched background population?
Hazard Ratio: 3.9 (95% CI 2.82–5.39)
p-value: p=<0.001
Aortic stenosis patients who survive the first three months after TAVR have a similar long-term survival rate to an age- and sex-matched general population, particularly those with low-to-intermediate risk and high transvalvular gradients.
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Early excess mortality after TAVR versus matched controls warrants periprocedural vigilance; leaves open whether contemporary techniques have reduced this gap.
Theut et al. (2017) conducted a cohort in Aortic stenosis (n=16,042). Transcatheter aortic valve replacement (TAVR) vs. Age- and sex-matched background population was evaluated on Early mortality (≤90 days) (HR 3.90, 95% CI 2.82-5.39, p=<0.001). TAVR was associated with higher early mortality (≤90 days) compared to matched controls (HR 3.90; 95% CI 2.82-5.39; p<0.001), but late mortality (>90 days) was similar between groups.
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