Key result
The intensity ratio µ, which describes the dominating rhythm, was correlated with atrial strain (r=-0.74) and AF burden (r=0.68), suggesting it may reflect the degree of atrial remodeling.
Why the study?
Studies evaluating AF risk factors have largely focused on AF presence and burden, disregarding the temporal distribution of AF episodes despite its potential clinical relevance.
Do parameters derived from an alternating, bivariate Hawkes model of AF episodes correlate with echocardiographic markers of atrial structural remodeling and AF burden in patients with paroxysmal AF?
Observational (n=14)
No
Do parameters derived from an alternating, bivariate Hawkes model of AF episodes correlate with echocardiographic markers of atrial structural remodeling and AF burden in patients with paroxysmal AF?
Effect estimate: r=0.68
p-value: p=<0.05
Hypothesis-generating for AF phenotyping; prospective validation needed before clinical risk assessment use.
Studies investigating risk factors associated with atrial fibrillation (AF) have mostly focused on AF presence and burden, disregarding the temporal distribution of AF episodes although such information can be relevant. In the present study, the alternating, bivariate Hawkes model was used to characterize paroxysmal AF episode patterns. Two parameters: the intensity ratio , describing the dominating rhythm (AF or non-AF) and the exponential decay 1 , providing information on clustering, were investigated in relation to AF burden and atrial echocardiographic measurements. Both and 1 were weakly correlated with atrial volume (r=0.19 and r=0.34, respectively), whereas was correlated with atrial strain (r=-0.74, p0.1) and AF burden (r=0.68, p0.05). Weak correlation between 1 and AF burden was found (r=0.29). Atrial structural remodeling is associated with changes in AF characteristics, often manifested as episodes of increasing duration, thus may reflect the degree of atrial electrical and structural remodeling. Moreover, clustering information ( 1 ) is complementary information to AF burden, which may be useful for understanding arrhythmia progression and risk assessment of ischemic stroke.
No takes yet. Share an insight, caveat, or question.
Martín-Yebra et al. (2020) conducted an observational in Paroxysmal atrial fibrillation (n=14). Alternating, bivariate Hawkes model parameters (µ and β1) was evaluated on Correlation between intensity ratio µ and AF burden (r=0.68, p=<0.05). The intensity ratio µ, which describes the dominating rhythm, was correlated with atrial strain (r=-0.74) and AF burden (r=0.68), suggesting it may reflect the degree of atrial remodeling.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: