Key result
Jiedu Huoxue Decoction improves post-MI LV function and inhibits cardiomyocyte apoptosis via PTEN/AKT/GSK3β pathway suppression.
Why the study?
Novel therapies specifically suppressing cardiomyocyte apoptosis via improving mitochondrial dysfunction following MI are urgently needed, and JDHXD may ameliorate post-MI myocardial injury.
JDHXD protects against oxidative stress-induced cardiomyocyte apoptosis post-MI by ameliorating mitochondrial dysfunction via suppression of the PTEN/AKT/GSK3β pathway.
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Hypothesis-generating for Jiedu Huoxue Decoction post-MI; leaves open human translation of PTEN/AKT/GSK3β modulation.
Pang et al. (2026) studied Myocardial infarction. Jiedu Huoxue Decoction (JDHXD) vs. captopril was evaluated on Cardiac function, apoptosis, oxidative stress, and mitochondrial dynamics. Jiedu Huoxue Decoction improved left ventricular function and inhibited cardiomyocyte apoptosis post-myocardial infarction by suppressing the PTEN/AKT/GSK3β pathway.
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