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July 1, 2026Discover NanoOpen Access

Tamoxifen loaded lipid nanoparticles as a novel therapeutic approach enhancing apoptotic cell death in triple negative breast cancer cells

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Authors

SGSevval GunbaySSSevgi Sarigul-OzbekEÇEgemen Çakırlı

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Overview

Randomized trial evaluates tamoxifen-loaded lipid nanoparticles to enhance therapeutic efficacy in triple-negative breast cancer, indicating a novel treatment strategy.

Key Points

  • This study aims to develop and characterize tamoxifen-loaded lipid nanoparticles for enhanced treatment of triple-negative breast cancer.
  • Developed solid lipid nanoparticles and nanostructured lipid carriers for tamoxifen delivery.
  • Characterized nanoparticles regarding size, zeta potential, entrapment efficiency, and drug release.
  • Assessed anti-tumor efficacy using cell viability and flow cytometry analysis in TNBC cells.
  • Tamoxifen-loaded lipid nanoparticles showed high entrapment efficiency (over 90%) and small size (< 200 nm).
  • NLCs released tamoxifen more effectively than SLNs, which exhibited retarded release.
  • Tamoxifen-loaded nanoparticles significantly reduced cell viability in MDA-MB-231 cells, primarily via apoptosis.

Cite This Study

Gunbay et al. (2026) studied this question.

synapsesocial.com/papers/6a44ada75cd2549c8bc43145https://doi.org/10.1186/s11671-026-04750-z
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