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July 1, 2026Clinical and Experimental MedicineOpen Access

Clonal Metamorphosis: Deconstructing MPN Evolution with Single-Cell and Spatial Multi-Omics

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Authors

MIMuhammad Shahid IqbalAAAbdullah K. AlahmariMKMohd Faiyaz Khan

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Overview

Review synthesizes advances in single-cell and spatial multi-omics to unveil MPN evolution and heterogeneity.

Key Points

  • The aim is to elucidate the evolutionary dynamics of myeloproliferative neoplasms (MPNs) using advanced multi-omic technologies.
  • Synthesis of recent advances in single-cell and spatial multi-omic technologies
  • Analysis of clonal architectures through targeted single-cell DNA sequencing
  • Integration of transcriptomic, epigenomic, and spatial data for profiling cellular and microenvironment interactions.
  • Reconstruction of clonal phylogenies reveals complex mutation order and co-mutation context
  • Identification of within-clone heterogeneity impacting therapy responses
  • Discovery of microenvironmental changes that promote aggressive subclones in MPNs.

Cite This Study

Iqbal et al. (2026) studied this question.

synapsesocial.com/papers/6a44add75cd2549c8bc43428https://doi.org/10.1007/s10238-026-02246-9
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