Key result
Lower skeletal muscle mass and handgrip strength link to higher arterial stiffness in hospitalized T2DM.
Why the study?
Sarcopenia is prevalent in T2DM and may increase cardiovascular risk, but the associations of skeletal muscle mass and strength with arterial stiffness in T2DM remain unclear.
Are skeletal muscle mass and strength associated with arterial stiffness in hospitalized patients with type 2 diabetes?
Cross-Sectional (n=281)
Are skeletal muscle mass and strength associated with arterial stiffness in hospitalized patients with type 2 diabetes?
Effect estimate: β = -0.247 for SMI; β = -0.212 for HS
p-value: P = 0.009 for SMI; P = 0.002 for HS
Lower skeletal muscle mass and handgrip strength are independently associated with increased arterial stiffness in patients with type 2 diabetes, suggesting sarcopenia parameters may serve as complementary markers for vascular risk.
Lower muscle parameters may mark vascular risk in T2DM; hypothesis-generating and should not yet change practice.
Sarcopenia is prevalent in people with type 2 diabetes mellitus (T2DM) and may contribute to increased cardiovascular risk. However, the associations of skeletal muscle mass and strength with arterial stiffness in T2DM remain unclear. This retrospective cross-sectional study included 281 hospitalized people with T2DM. Arterial stiffness was assessed by brachial-ankle pulse wave velocity (baPWV), and skeletal muscle mass index (SMI) and handgrip strength (HS) were evaluated. Associations with baPWV were examined using correlation and multivariable linear regression analyses. baPWV was inversely associated with both SMI and HS. In multivariable analyses, lower SMI (β = -0.247, P = 0.009) and lower HS (β = -0.212, P = 0.002) were significantly associated with higher arterial stiffness after adjustment for established cardiovascular risk factors. Both skeletal muscle mass and strength were associated with arterial stiffness in individuals with T2DM. Assessment of both parameters may provide complementary information regarding vascular risk.
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Koike et al. (2026) conducted a cross-sectional in Type 2 diabetes mellitus (n=281). Skeletal muscle mass index (SMI) and handgrip strength (HS) was evaluated on Arterial stiffness assessed by brachial-ankle pulse wave velocity (baPWV) (β = -0.247 for SMI; β = -0.212 for HS, p=P = 0.009 for SMI; P = 0.002 for HS). Lower skeletal muscle mass index (β = -0.247, P = 0.009) and handgrip strength (β = -0.212, P = 0.002) were significantly associated with higher arterial stiffness in hospitalized patients with T2DM.
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