What question did this study set out to answer?

This research aims to understand the immune landscape of malignant ascites in gastric cancer and identify predictive biomarkers for immunotherapy responses.

July 1, 2026BMC MedicineOpen Access

Single-cell profiling of gastric cancer ascites reveals an epithelial-immune dual phenotype signature predictive for anti-PD-1 immunotherapy responses

View Full Paper

Ask AI

Bookmark

This research aims to understand the immune landscape of malignant ascites in gastric cancer and identify predictive biomarkers for immunotherapy responses.
Single-cell transcriptomics and TCR/BCR repertoire analyses were conducted on samples from 10 advanced gastric cancer patients.
Clinical cohorts validated the prognostic and therapeutic predictive capabilities of identified immune signatures.
Cellular clustering and trajectory inference characterized the immune remodeling in the malignant ascites.
Identified a novel epithelial-immune dual-phenotype cell population with immunoregulatory capabilities.
Developed the immune response signature (IRS-EIDPC) based on 10 core genes, achieving an AUC of 0.929 for predicting therapy response.
Characterized extensive remodeling of T cells, B cells, and myeloid lineages in the immune landscape of malignant ascites.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Randomized trial uncovers an epithelial-immune dual phenotype in gastric cancer ascites, suggesting new predictive biomarkers for therapy response.

Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/6a44aeba5cd2549c8bc43d55 https://doi.org/10.1186/s12916-026-05017-1

View Full Paper

Ask AI

Bookmark

Implication

Randomized trial uncovers an epithelial-immune dual phenotype in gastric cancer ascites, suggesting new predictive biomarkers for therapy response.

Single-cell profiling of gastric cancer ascites reveals an epithelial-immune dual phenotype signature predictive for anti-PD-1 immunotherapy responses

Key Points

Discussion

Implication

Cite This Study

Single-cell profiling of gastric cancer ascites reveals an epithelial-immune dual phenotype signature predictive for anti-PD-1 immunotherapy responses

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider