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July 1, 2026Communications BiologyOpen Access

Multi-omics reveals tumor microenvironment heterogeneity and therapeutic vulnerabilities in peritoneal metastasis of gastric cancer

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Authors

WXWen XieZWZhenfa WangPLPeiyu Lv

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Overview

Randomized trial evaluates therapeutic targets in gastric cancer peritoneal metastasis, highlighting potential treatment strategies.

Key Points

  • The study aims to understand the tumor microenvironment and identify potential therapeutic targets in peritoneal metastasis of gastric cancer.
  • Utilized single-cell RNA sequencing (scRNA-seq) to analyze cellular composition of the tumor microenvironment.
  • Integrated spatial transcriptomics and multiplex immunohistochemistry for target validation.
  • Conducted in vivo mouse models to assess the efficacy of dual targeting therapy.
  • Identified a PM signature linked to cancer cell differentiation, with PM-high associated with multiple oncogenic pathways.
  • In vivo targeting of TIGIT and CLDN18.2 demonstrated significant inhibition of PMGC progression and ascites formation.
  • Supported combined targeting of TIGIT and CLDN18.2 as a promising therapeutic strategy.

Cite This Study

Xie et al. (2026) studied this question.

synapsesocial.com/papers/6a44afdc5cd2549c8bc44b02https://doi.org/10.1038/s42003-026-10571-8
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Spatially resolved niche and tumor microenvironmental alterations in gastric cancer peritoneal metastases2024 · 2 citations
  2. 2Transcriptome Dynamics From Primary Gastric Cancer to Peritoneal Metastases: Translational Insights for Surgical Oncology2026
  3. 3Comprehensive analysis of the tumor immune microenvironment in gastric cancer and peritoneal metastasis based on single-cell RNA sequencing analysis2025
  4. 4Divergent clonal evolution and tumor microenvironment remodeling shape gastric cancer peritoneal metastasis2026
  5. 5Targeting the remodeled peritoneal ecosystem: a paradigm shift from tumor cells to the microenvironment in gastric cancer peritoneal metastasis2026