What question did this study set out to answer?

This study aims to develop a monitoring platform for thrombo-inflammatory biomarkers to enable early detection of cardiovascular risks.

July 1, 2026Advanced Materials

In Vivo Monitoring of Thrombo‐Inflammatory Biomarkers via Molecularly Imprinted Polymer‐Integrated Hydrogel Microneedles

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This study aims to develop a monitoring platform for thrombo-inflammatory biomarkers to enable early detection of cardiovascular risks.
Developed a wearable electrochemical biosensor integrating Prussian Blue, MIPs, and hydrogel microneedles.
Conducted in vitro and ex vivo testing on porcine skin to evaluate performance.
Performed in vivo testing on LPS-challenged rats to monitor changes in interstitial fluid over 0–24 h.
Achieved limits of detection of 0.26 ng mL−1 for thrombin and ≤ 0.41 pg mL−1 for IL-6 and TNF-α.
Observed direct capture of thrombin and IL-6 levels over time with validated results against ELISA tests.
Demonstrated the capability for continuous monitoring of thrombo-inflammatory activity in real-time.

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Implication

Randomized trial demonstrates real-time detection of thrombo-inflammatory biomarkers in rats, suggesting potential for early cardiovascular risk assessment.

Cite This Study

Saleh et al. (2026) studied this question.

synapsesocial.com/papers/6a44af055cd2549c8bc4416d https://doi.org/10.1002/adma.202521589

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Implication

Randomized trial demonstrates real-time detection of thrombo-inflammatory biomarkers in rats, suggesting potential for early cardiovascular risk assessment.

In Vivo Monitoring of Thrombo‐Inflammatory Biomarkers via Molecularly Imprinted Polymer‐Integrated Hydrogel Microneedles

Key Points

Discussion

Implication

Cite This Study

In Vivo Monitoring of Thrombo‐Inflammatory Biomarkers via Molecularly Imprinted Polymer‐Integrated Hydrogel Microneedles

Key Points

Discussion

Implication

Cite This Study

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