Key result
A molecularly imprinted polymer-grafted electrode demonstrated a 20-second response time to heparin concentration changes and successfully detected heparin in diluted whole blood samples.
A novel molecularly imprinted polymer-grafted electrode enables rapid, real-time sensing of heparin in blood, potentially improving safety during surgeries and extracorporeal therapies.
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Preclinical heparin sensor feasible in blood; leaves open clinical translation and human validation before practice change.
Yoshimi et al. (2013) studied Heparin monitoring. Molecularly imprinted polymer (MIP) grafted electrode vs. Conventional methods was evaluated on Response time to stepwise changes in heparin concentration and detection in whole blood. A molecularly imprinted polymer-grafted electrode demonstrated a 20-second response time to heparin concentration changes and successfully detected heparin in diluted whole blood samples.
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