10-Year Trends in Attributable and Contributable Mortality of Culture-Positive Invasive Aspergillosis in Patients with Hematologic Malignancies: Have We Reached the “Ceiling Efficacy Effect” of Modern Antifungals?

Ariel D. Szvalb; Sebastian Wurster; Takahiro Matsuo; Teny M. John; Adam G. Stewart; Sung‐Yeon Cho; Yan Jiang; Dimitrios P. Kontoyiannis

doi:10.1093/cid/ciag393

June 29, 2026Clinical Infectious Diseases

10-Year Trends in Attributable and Contributable Mortality of Culture-Positive Invasive Aspergillosis in Patients with Hematologic Malignancies: Have We Reached the “Ceiling Efficacy Effect” of Modern Antifungals?

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Key Points

The research aims to evaluate mortality rates related to invasive aspergillosis in patients with hematologic malignancies over a 10-year period.
Assessed culture-positive invasive aspergillosis cases among patients with hematologic malignancies.
Analyzed trends in attributable, contributable, and all-cause mortality.
Compared data over a decade to determine changes in mortality rates.
Attributable mortality decreased over the 10 years, suggesting some effectiveness of treatment.
Contributable and all-cause mortalities remained high, indicating persistent vulnerability in these patients.
Suggests that improving patient survival requires additional strategies beyond improved antifungal therapy.

Implication

Assesses mortality trends in invasive aspergillosis patients with hematologic malignancies, indicating a need for host enhancement alongside antifungal treatment.

Abstract

Given competing death causalities among hematological malignancy patients with invasive aspergillosis (IA), we assessed IA-attributable, contributable, and all-cause mortalities in patients with culture-confirmed IA. Although attributable mortality decreased, contributable and all-cause mortalities remained high. Our data suggest that improving survival would require host augmentation, in addition to improved antifungals.

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Cite This Study

Szvalb et al. (2026) studied this question.

synapsesocial.com/papers/6a44af055cd2549c8bc44192 https://doi.org/10.1093/cid/ciag393

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10-Year Trends in Attributable and Contributable Mortality of Culture-Positive Invasive Aspergillosis in Patients with Hematologic Malignancies: Have We Reached the “Ceiling Efficacy Effect” of Modern Antifungals?

Key Points

Implication

Abstract

Discussion

Cite This Study

10-Year Trends in Attributable and Contributable Mortality of Culture-Positive Invasive Aspergillosis in Patients with Hematologic Malignancies: Have We Reached the “Ceiling Efficacy Effect” of Modern Antifungals?

Key Points

Implication

Abstract

Discussion

Cite This Study

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