Key result
Five IBV isolates from vaccinated chickens in the Middle East were identified as strain CK/CH/LDL/97I, sharing 96.6-99.1% nucleotide identity with the reference strain and <80% with vaccine strains.
Observational (n=5)
Yes
This study documents for the first time the presence of the Chinese/Taiwanese IBV strain CK/CH/LDL/97I in the Middle East, potentially explaining vaccination failures in local poultry.
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May indicate IBV vaccination failures in Middle Eastern poultry; hypothesis-generating for updated regional vaccines.
Infectious bronchitis virus (IBV) is a very dynamic and evolving virus, causing major economic losses to the global poultry industry. In early 2011, respiratory disease outbreaks were investigated in Iraq, Jordan, and Saudi Arabia. Five IBV isolates (JOA2, JOA4, Saudi-1, Saudi-2, and Iraqi IBV) were detected by diagnostic-nested nucleocapsid RT-PCR. Strain identification was characterised by sequencing and phylogenetic analysis of the amplified hypervariable region of the spike 1 (S1) gene. These five IBV isolates were found to be of the IBV strain CK/CH/LDL/97I. Nucleotide identity between these five IBV isolates ranged from 96.9% to 99.7%, and between these isolates and the CK/CH/LDL/97I strain in the range of 96.6-99.1%. The sequenced fragment of the S1 gene of the CK/CH/LDL/97I strain had less than 80% nucleotide identity to the IBV vaccine strains commonly used in the Middle East (M41 and H120). The presence of these CK/CH/LDL/97I-like strains may account for vaccination failure against IBV, since all IBV isolates were from vaccinated chickens. In this paper, we documented for the first time the presence of IBV strain CK/CH/LDL/97I in the Middle East. This strain is known to have originated in China and Taiwan.
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Ababneh et al. (2012) conducted an observational in Infectious bronchitis virus (IBV) in poultry (n=5). IBV strain CK/CH/LDL/97I was evaluated on Nucleotide identity of the S1 gene hypervariable region. Five IBV isolates from vaccinated chickens in the Middle East were identified as strain CK/CH/LDL/97I, sharing 96.6-99.1% nucleotide identity with the reference strain and <80% with vaccine strains.
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