Key result
In Maine Coon cats, the prevalence of MYBPC3-A31P and -A74T mutations was 16.33% and 22.45%, respectively, and these mutations were associated with tachycardia and prolonged isovolumic relaxation time.
Why the study?
Hypertrophic cardiomyopathy is common in cats and can cause sudden death or congestive heart failure, motivating assessment of MYBPC3 polymorphisms and risk factors for diagnosis.
Cross-Sectional (n=49)
No
Odds Ratio: 0.72 (95% CI 0.1272–4.0507)
Absolute Event Rate: 25% vs 31.7%
MYBPC3-A31P and -A74T mutations are prevalent in Maine Coon cats and are associated with clinical and echocardiographic markers of hypertrophic cardiomyopathy, particularly prolonged isovolumic relaxation time.
May inform genetic screening in Maine Coon cats; leaves open larger studies before guiding practice.
Background and Aim: Hypertrophic cardiomyopathy (HCM) is a common heart problem that affects many cats. Although cats with HCM are symptomatic, some die suddenly or develop congestive heart failure. Therefore, this study aimed to estimate the prevalence of myosin-binding protein C3 (MYBPC3), A31P, and A74T polymorphisms in Maine Coon cats to assess risk factors for diagnosing HCM in cats. Materials and Methods: Forty-nine Maine Coon cats of at least 10 months of age were enrolled in this study. First, clinical parameters, such as heart rate, systolic blood pressure, and echocardiography, were evaluated. Then, polymerase chain reaction, followed by DNA sequencing, was conducted using specific primers for amino acid substitutions caused by genetic variants of MYBPC3-A31P and -A74T polymorphisms. Results: Investigations showed that the prevalence of MYBPC3-A31P and -A74T mutations in this study was 16.33% and 24.45%, respectively. Moreover, HCM in cats with MYBPC3-A31P and A74T mutations increased with age, body weight, high heart rate, and prolonged isovolumic relaxation time. Conclusion: Therefore, we propose that Maine Coon cats develop HCM due to multiple genetic factors and underlying clinical characteristics in individual cats. Furthermore, relaxation time assessments can be a sensitive technique for HCM screening during its preclinical phase and can help identify the risk of developing HCM. However, further studies are warranted to evaluate the effect of MYBPC3 mutations on the phenotypic expression of HCM.
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Sukumolanan et al. (2022) conducted a cross-sectional in Hypertrophic cardiomyopathy (n=49). MYBPC3-A31P mutation vs. Wild-type (no mutation) was evaluated on Hypertrophic cardiomyopathy (OR 0.72, 95% CI 0.1272-4.0507). In Maine Coon cats, the prevalence of MYBPC3-A31P and -A74T mutations was 16.33% and 22.45%, respectively, and these mutations were associated with tachycardia and prolonged isovolumic relaxation time.
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