Key result
Frequent inhalation of inhaled corticosteroids/long-acting beta2-adrenoceptor agonists during a severe asthmatic attack triggered Takotsubo cardiomyopathy in a 63-year-old man.
Case Report (n=1)
Takotsubo cardiomyopathy can be triggered by an asthmatic attack and the frequent use of inhaled corticosteroids/long-acting beta2-adrenoceptor agonists due to catecholamine elevation.
Case report raises possibility of Takotsubo after asthma treatment; leaves open causal link pending larger studies.
A 63-year-old man was transferred to our hospital because of an exacerbation of asthma. His symptoms deteriorated even after increasing the dose of inhaled corticosteroids/long-acting beta2-adrenoceptor agonists (ICS/LABA). He had no chest pain and an electrocardiogram revealed ST elevation. A coronary angiogram revealed a reduced left ventricular function with an apical ballooning pattern without coronary stenosis. He was diagnosed with Takotsubo cardiomyopathy. Catecholamine elevation due to acute asthma and an overdose of ICS/LABA may be triggers of this disease. We should remember that Takotsubo cardiomyopathy is a complication of asthma and that catecholamine plays an important role in its onset, although it is essential for asthma treatment.
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Saito et al. (2016) conducted a case report in Asthmatic attack complicated with Takotsubo cardiomyopathy (n=1). Frequent inhalation of inhaled corticosteroids/long-acting beta2-adrenoceptor agonists (ICS/LABA) was evaluated. Frequent inhalation of inhaled corticosteroids/long-acting beta2-adrenoceptor agonists during a severe asthmatic attack triggered Takotsubo cardiomyopathy in a 63-year-old man.
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