Key result
Troponins and BNPs are key cardiac biomarkers used alongside clinical scores and imaging for the prognostic stratification and management of acute pulmonary embolism.
Why the study?
The major challenge of initial management in acute pulmonary embolism lies in prognostic stratification, prompting an update on the role of troponins and BNPs and their place in current management.
What is the role of cardiac biomarkers (troponins and BNPs) in the prognostic stratification of patients with acute pulmonary embolism?
What is the role of cardiac biomarkers (troponins and BNPs) in the prognostic stratification of patients with acute pulmonary embolism?
Cardiac biomarkers such as troponins and BNPs play a crucial role in the prognostic stratification and management of acute pulmonary embolism.
Supports biomarker-guided PE risk stratification now; leaves open prospective validation for therapy decisions.
Pulmonary embolism is a frequent and potentially fatal disease. The major challenge of initial management lies in prognostic stratification. Since 2014, the European recommendations on the diagnosis and management of acute pulmonary embolism are based on assessing the risk stratification regarding hemodynamic status first, then on a combined risk assessment model using a clinical score, an imaging evaluation of right heart size and the concentration of a serum cardiac biomarker. Usual biomarkers cover cardiac ischemia (troponin and derivates) and dilatation (BNP and derivates). The aim of this review is to offer a practical update on the role of the Troponins and BNPs families of biomarkers and the prognosis of pulmonary embolism, and furthermore, to provide a brief overview of their place in current management.
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Janisset et al. (2022) conducted a review in Acute Pulmonary Embolism. Cardiac biomarkers (Troponins and BNPs) was evaluated on Prognostic stratification. Troponins and BNPs are key cardiac biomarkers used alongside clinical scores and imaging for the prognostic stratification and management of acute pulmonary embolism.
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