Key result
Combining genetically encoded voltage and calcium fluorescent reporters with hiPSC-CMs allowed reliable monitoring of action-potential and calcium-handling properties and arrhythmia development.
Population
Human-induced pluripotent stem cell-derived cardiomyocytes, including those derived from patients with…
Design
Preclinical
Authors
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Advances hiPSC phenotyping for arrhythmia research; leaves open clinical translation to drug testing.
Combining genetically encoded fluorescent reporters with hiPSC-CMs enables high-resolution functional phenotyping for disease modeling and drug testing.
Shinnawi et al. (2015) studied Inherited arrhythmogenic syndromes. Genetically encoded voltage (ArcLight) and calcium (GCaMP5G) fluorescent indicators was evaluated on Changes in transmembrane potential and intracellular calcium levels. Combining genetically encoded voltage and calcium fluorescent reporters with hiPSC-CMs allowed reliable monitoring of action-potential and calcium-handling properties and arrhythmia development.
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