September 1, 2015Current Protocols in Chemical BiologyOpen Access

Use of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes (hiPSC‐CMs) to Monitor Compound Effects on Cardiac Myocyte Signaling Pathways

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Population

Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)

Design

Preclinical

Authors

LGLiang GuoShanxi Normal University SESandy EldridgeFrederick National Laboratory for Cancer Research JMJodie MussioLeidos (United States)

Discussion

Member takes

Implication

Integrates multi-endpoint cardiomyocyte testing; leaves open translation to clinical cardiotoxicity assessment.

Structured PICO

Population

Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)

Intervention

Methodological workflow employing protocols to demonstrate protein expression and functional integrity of signaling pathways and characterize biological consequences of signaling modulation

Outcome

Demonstration of the presence and function of signaling pathways and the effects of treatments on these pathwayssurrogate

This paper provides a methodological workflow for using hiPSC-CMs to investigate cardiac myocyte signaling pathways and assess cardiotoxicity risk in drug discovery.

Cite This Study

Guo et al. (2015) studied this question.

synapsesocial.com/papers/6a83e6fab0b8dfdc4c62e047 https://doi.org/10.1002/9780470559277.ch150035

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Use of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes (hiPSC‐CMs) to Monitor Compound Effects on Cardiac Myocyte Signaling Pathways

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Use of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes (hiPSC‐CMs) to Monitor Compound Effects on Cardiac Myocyte Signaling Pathways

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider