Key result
Progressive hypotension with hypocapnia resulted in a 28 ml/min greater decline in vertebral artery blood flow compared to hypotension without hypocapnia (P=0.002).
Why the study?
Does hypocapnia during progressive hypotension alter regional cerebral blood flow and intracranial velocities in humans?
Population
Human participants
Comparison
Progressive lower-body negative pressure until… vs Progressive lower-body negative pressure until…
Design
Other
Authors
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Alerts to CO2 modulation of posterior cerebral flow during hypotension; leaves open targeted perioperative strategies.
Does hypocapnia during progressive hypotension alter regional cerebral blood flow and intracranial velocities in humans?
Mean Difference: -28
p-value: p=0.002
Vertebral artery blood flow is sensitive to both hypotension and hypocapnia, and arterial constriction in the internal carotid and vertebral arteries contributes to the decline in global cerebral blood flow during systemic hypotension.
Lewis et al. (2015) studied this question. Progressive hypotension with hypocapnia (poikilocapnic trial) vs. Progressive hypotension without hypocapnia (isocapnic trial) was evaluated on Decline in vertebral artery blood flow (VABF) (MD -28 ml/min, p=0.002). Progressive hypotension with hypocapnia resulted in a 28 ml/min greater decline in vertebral artery blood flow compared to hypotension without hypocapnia (P=0.002).