Key result
Spaceflight altered cerebral blood flow regulation, with nonfinishers of a post-flight stand test showing a greater decrease in mean blood flow velocity as a function of blood pressure than finishers.
Why the study?
Does space flight alter cerebral blood flow regulation during a stand test in astronauts?
Population
27 astronauts from shuttle missions lasting 8 to 16 days
Comparison
10-minute stand test performed 10 days before… vs Pre-flight vs post-flight, and finishers vs…
Design
Cohort
Follow-up
3 days after landing
Authors
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May indicate gender differences in astronaut orthostatic tolerance; hypothesis-generating and not ready for clinical translation.
Observational (n=27)
Does space flight alter cerebral blood flow regulation during a stand test in astronauts?
p-value: p=<0.001
Presyncope in astronauts after space flight may be related to a mismatch of cerebral blood flow with blood pressure, with potential gender differences in susceptibility.
Blaber et al. (2011) conducted an observational in Orthostatic intolerance (n=27). Spaceflight vs. Preflight baseline was evaluated on Blood pressure at the level of the middle cerebral artery (BP(MCA)) and cerebrovascular conductance during a stand test (p=<0.001). Spaceflight altered cerebral blood flow regulation, with nonfinishers of a post-flight stand test showing a greater decrease in mean blood flow velocity as a function of blood pressure than finishers.
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