November 8, 2011Hypertension
Plasma Aldosterone Levels and Development of Insulin Resistance
Key result
The highest tertile of plasma aldosterone levels was associated with an increased risk of developing insulin resistance over 10 years compared to the lowest tertile (RR 1.71; 95% CI 1.03-2.84; P<0.05).
Why the study?
Do higher plasma aldosterone levels predict the development of insulin resistance in a general population?
Population
1235 local residents participating in health screenings in Japan; prospective analysis included 564…
Comparison
Highest tertile of plasma aldosterone levels vs Lowest tertile of plasma aldosterone levels
Design
Cohort
Follow-up
10 years
Authors
Discussion
Loading...
Member takes
Implication
Should not yet change diabetes management; leaves open aldosterone's causal role in insulin resistance.
Study Design
Type
Cohort (n=1,235)
Structured PICO
Do higher plasma aldosterone levels predict the development of insulin resistance in a general population?
P
Population
1,235 local residents in Japan, including a prospective cohort of 564 nondiabetic subjects followed for 10 years to predict incident insulin resistance.
E
Exposure
Highest tertile of plasma aldosterone levels
C
Comparator
Lowest tertile of plasma aldosterone levels
O
Outcome
Development of insulin resistance (homeostasis model assessment index ≥1.73)surrogate
Main Result
Relative Risk: 1.71 (95% CI 1.03–2.84)
p-value: p=<0.05
Higher plasma aldosterone levels independently predict the development of insulin resistance over a 10-year period in a general Japanese population.
Cite This Study
Kumagai et al. (2011) conducted a cohort in Insulin resistance (n=1,235). High plasma aldosterone levels (highest tertile) vs. Lowest tertile of plasma aldosterone was evaluated on Development of insulin resistance (RR 1.71, 95% CI 1.03-2.84, p=<0.05). The highest tertile of plasma aldosterone levels was associated with an increased risk of developing insulin resistance over 10 years compared to the lowest tertile (RR 1.71; 95% CI 1.03-2.84; P<0.05).