Nuclear adaptation in cell migration

Cells in tissues often navigate complex environments, encountering physical obstacles which impose mechanical confinement. The nucleus -the largest organelle of the eukaryotic cell-is emerging as a key platform for integrating mechanical signals from the extracellular environment. A mechanically stiff nucleus often limits migration through confinement. It is becoming increasingly clear that the nucleus does not passively resist forces. Subnuclear organisation can change upon mechanical stress, revealing an impressive capability for adaptation to environmental challenges that underpins cell function, developmental potential and can support invasion and migration both in physiology and disease.