Randomized trial demonstrates changes in neuroblastoma uptake in a pediatric patient, suggesting disease progression.
A 5-year-old girl diagnosed with high-risk neuroblastoma enrolled in our clinical trial underwent 18F-MFBG PET/CT, showing multiple discrete focal "hot spots." Bone marrow aspiration confirmed metastatic neuroblastoma involvement. After 5 cycles of immunotherapy and chemotherapy, follow-up 18F-MFBG PET/CT revealed a marked shift in biodistribution: the multiple discrete focal "hot spots" pattern resolved, and diffuse and intense skeletal tracer uptake-consistent with a superscan pattern emerged-including both newly developed lesions-indicative of progressive disease. The present case showed the temporal evolution of 18F-MFBG uptake from multiple focal "hot spots" to a superscan.
No takes yet. Share an insight, caveat, or question.
Wang et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: