What question did this study set out to answer?

The aim is to review literature on factors contributing to interobserver variability (IOV) in RECIST assessments.

July 2, 2026Insights into ImagingOpen Access

Assessing the reliability of Response Evaluation Criteria In Solid Tumors (RECIST): a systematic review of the factors contributing to inter-observer variability

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Systematic review identifies factors affecting interobserver variability in RECIST assessments, indicating the need for standardization.

The aim is to review literature on factors contributing to interobserver variability (IOV) in RECIST assessments.
Conducted a systematic review of 246 studies focusing on RECIST assessments.
Included studies with manual measurements, lesion selection, and imaging quality.
Evaluated statistical methods used for measuring IOV.
88 studies met the inclusion criteria, with a median sample size of 50 patients.
68.2% of studies used CT scans as the primary imaging modality.
Findings indicated IOV is influenced by measurement methods, lesion selection, and imaging quality.

Smesseim et al. (2026) studied this question.

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