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The study aims to formulate and evaluate a buccal patch of Metronidazole for enhancing treatment of periodontitis.

July 2, 2026Open Access

A Review on Formulation and Evaluation of Buccal Patches of Metronidazole for the Treatment of Periodontitis

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Review evaluates metronidazole buccal patches for treating periodontitis, suggesting improved patient compliance.

The study aims to formulate and evaluate a buccal patch of Metronidazole for enhancing treatment of periodontitis.
Buccal patches were prepared using solvent casting method with Hydroxypropyl Methylcellulose and glycerine.
Formulations F1–F5 were developed varying polymer and excipient concentrations.
Evaluation included parameters such as weight uniformity, thickness, folding endurance, and surface pH.
All formulations exhibited satisfactory physicochemical properties.
Batch F3 showed optimal weight uniformity, thickness, folding endurance, and suitable surface pH.
Buccal patches demonstrated good flexibility and compatibility with buccal mucosa.

*1Prachi Dukhande, 2Ronal Dsilva, 3Srushti Davari, 4Roshan Gamare, 5Ms. Manasi Mathkar (2026) studied this question.

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