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July 2, 2026Alcohol Clinical and Experimental Research

A Secondary, Subgroup Analysis of Alcohol Cue‐Exposure Craving in Response to Pharmacological Inhibition of the Growth Hormone Secretagogue Receptor With PF ‐5190457

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Authors

RTRyan E. TylerVAValerie Espinal AbreuMFMehdi Farokhnia

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Overview

Secondary analysis explores how PF‐5190457 affects craving for alcohol in different AUD subgroups, suggesting potential benefits.

Key Points

  • To analyze how PF‐5190457 affects alcohol craving in specific subgroups of individuals with alcohol use disorder.
  • Secondary analysis of two placebo-controlled studies combining data from active drinkers and abstinent inpatients.
  • Subgroups based on alcohol cue-reactivity and Penn Alcohol Craving Scale scores were created.
  • Craving measured using the Alcohol Urge Questionnaire after relaxation and cue trials.
  • PF‐5190457 reduced craving scores in the ‘cue-reactor’ subgroup after the alcohol cue trial.
  • Reduction in craving also observed in PACS high cravers during both trials, while PACS low cravers showed no change.
  • No significant effect on cue-reactivity across any subgroup.

Cite This Study

Tyler et al. (2026) studied this question.

synapsesocial.com/papers/6a4601cc9ed13430313119b5https://doi.org/10.1111/acer.70366
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