Key result
CAC of 0 or ≤10 is linked to ~80% lower coronary heart disease risk in older adults.
Why the study?
Do negative risk markers such as CAC=0 identify elderly individuals at low short-term risk for coronary heart disease and cardiovascular disease?
Observational (n=5,805)
Do negative risk markers such as CAC=0 identify elderly individuals at low short-term risk for coronary heart disease and cardiovascular disease?
Effect estimate: mean DLR 0.20
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Negative risk markers, particularly CAC=0 and CAC≤10, accurately identify elderly individuals at remarkably low cardiovascular risk, suggesting that universal risk-based statin eligibility may lead to overtreatment.
Mortensen et al. (2019) conducted an observational in Cardiovascular risk (n=5,805). Negative risk markers (e.g., CAC = 0, CAC ≤10, low galectin-3, no carotid plaque) vs. Traditional risk factor assessment was evaluated on Coronary heart disease and cardiovascular disease (mean DLR 0.20). Coronary artery calcium scores of 0 or ≤10 were the strongest negative risk markers for coronary heart disease in the elderly (mean DLR 0.20), indicating ≈80% lower risk than expected.