Key result
Diabetic autonomic neuropathy impairs cardiac parasympathetic function universally and sympathetic control in most patients.
Why the study?
Does diabetic autonomic neuropathy cause defective efferent autonomic control of the heart?
Cross-Sectional (n=13)
No
Does diabetic autonomic neuropathy cause defective efferent autonomic control of the heart?
Diabetic autonomic neuropathy profoundly impairs vagal and sympathetic cardiac innervation, which can lead to fixed heart rates and potentially fatal dysrhythmias.
May predispose diabetic autonomic neuropathy patients to fixed rates and arrests; leaves open prospective validation of autonomic testing.
Heart rate responses to autonomic stimulation and inhibition were studied in 13 diabetic autonomic neuropathy. Parasympathetic function was impaired in all patients and sympathetic function in most. One patient's heart appeared to be totally denervated. The consequences of cardiac denervation include tachycardia, a fixed heart rate, and a possible tendency to cardiac dysrhythmias, which caused spontaneous cardiac arrests in three patients.
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Lloyd‐Mostyn et al. (1975) conducted a cross-sectional in Diabetic autonomic neuropathy (n=13). Diabetic autonomic neuropathy vs. Healthy normal subjects was evaluated on Heart rate responses to autonomic stimulation and inhibition. Parasympathetic function was impaired in all 13 patients and sympathetic function was impaired in most, demonstrating defective innervation of the heart in diabetic autonomic neuropathy.
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