Key result
Transcatheter pulmonary valve replacement provides comparable long-term results to surgical replacement for restoring right ventricular outflow tract function in patients with congenital heart disease.
Why the study?
Multiple surgical pulmonary valve replacements for degenerated RVOT conduits carry cumulative risks, making transcatheter pulmonary valve replacement a valuable non-surgical alternative.
Does transcatheter pulmonary valve replacement restore RVOT and RV function in patients with congenital heart diseases and RVOT dysfunction?
Does transcatheter pulmonary valve replacement restore RVOT and RV function in patients with congenital heart diseases and RVOT dysfunction?
Transcatheter pulmonary valve replacement is a valuable non-surgical alternative to surgical pulmonary valve replacement with comparable long-term results for restoring RVOT function in congenital heart disease patients.
May support TPVR as alternative in congenital RVOT disease; leaves open prospective trials for native anatomy.
Surgical repair of a variety of congenital heart diseases involves repair of the right ventricular outflow tract (RVOT) with valved or non-valved conduit to connect the right ventricle (RV) to the pulmonary artery (PA) or just patch enlargement of the native RVOT. With time, this RV-PA conduit will degenerate with deterioration of function, either causing pulmonary stenosis or pulmonary regurgitation. This RVOT dysfunction may result in RV dilation, RV dysfunction, and eventual RV failure and arrhythmias. Multiple surgical pulmonary valve replacement (PVR) is often required throughout the patient's lifetime. Patients are subjected to increased risks with each additional cardiac operation. Transcatheter PVR (TPVR) has been developed over the past two decades as a valuable non-surgical alternative to restore the RVOT and RV function, and hence reduce patients' lifetime risks related to surgery. This article will discuss the long-term results of TPVR which are demonstrated to be comparable to surgical results and the latest development of large pulmonary valves which will allow TPVR to be performed on native or larger RVOT.
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Adolphus Kai-tung Chau (2022) conducted a review in Congenital heart disease. Transcatheter pulmonary valve replacement vs. Surgical pulmonary valve replacement was evaluated. Transcatheter pulmonary valve replacement provides comparable long-term results to surgical replacement for restoring right ventricular outflow tract function in patients with congenital heart disease.
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