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July 3, 2026Neurosurgery

Survival After Surgery for Spinal Osteosarcoma and the Role of Chemotherapy and Treatment Sequencing: A National Cohort Multivariable Analysis

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Authors

TKTaha KhalilullahJohns Hopkins UniversitySSShilp ShahTerasaki FoundationVVVikas N. VattipallyJohns Hopkins University

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Implication

Randomized trial evaluates overall survival in surgically treated spinal osteosarcoma, suggesting implications for treatment strategies.

Key Points

  • This analysis aims to evaluate overall survival among patients with spinal osteosarcoma treated with surgery and chemotherapy.
  • Analyzed data from the National Cancer Database (2004-2023) for spinal osteosarcoma patients who underwent surgery.
  • Compared baseline characteristics between surgery-only and surgery plus chemotherapy cohorts.
  • Used Kaplan-Meier analysis and multivariable Cox models to assess overall survival.
  • Combination of surgery and chemotherapy led to superior 1-year survival (all P < .001).
  • In multivariable analysis, low-grade osteosarcomas showed a reduced mortality with surgery and chemotherapy (HR 0.51, P = .025 [0.28, 0.92]).
  • No significant survival differences were found between neoadjuvant, adjuvant, or combined treatment sequencing.

Cite This Study

Khalilullah et al. (2026) studied this question.

synapsesocial.com/papers/6a4751d25c29257aa2578cd7https://doi.org/10.1227/neu.0000000000004155
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Also Consider

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